Scientists say child has been 'functionally cured' of HIV infection with early treatment

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Scientists say child has been 'functionally cured' of HIV infection with early treatment

Post by BarrileteCosmico on Tue Mar 05, 2013 1:22 pm

Medical researchers announced today that, for the first time, a child born with HIV appears to have been cured. Doctors are hopeful that the results may be replicated and used to treat infants infected by pregnancy or delivery in the first few days of life.

"Despite ending treatment the child now has no identifiable levels of HIV"

According to the National Institutes of Health, a two-year old child born with HIV — the virus responsible for AIDS — is now "functionally cured" of the infection following the early administration of antiretroviral therapy. Doctors initially detected small levels of the virus in the baby, concluding that the infection occurred before the infant's premature birth in July 2010, and began treatment of a liquid antiretroviral around 30 hours of age. The infant's HIV-infected mother reportedly had received no antiretroviral medication or prenatal care, and was unaware she had been infected with the virus. After 18 months of treatment, the child was taken off therapy "for reasons that are unclear," but doctors say that despite ending treatment the child now has no identifiable levels of HIV in the body.

Scientists say it's an unprecedented development; according to NIH, it's the first well-documented case of an HIV-infected child who has been cured of the infection. According to The New York Times, the lead author on today's report, Dr. Deborah Persaud of the Johns Hopkins Children's Center, says that "it's proof of principle that we can cure HIV infection if we can replicate this case." Persaud says that "for pediatrics, this is our Timothy Brown," in reference to the only other person known to have been cured of HIV. Brown, an adult, was cured via a risky bone-marrow transplant that's difficult to replicate.

""We may have a promising lead for additional research toward curing other children.""

While the results are stunning and promising, the researchers in the study say that further research will be required to know whether this child's experience can be replicated in clinical trials with other HIV-infected children. The New York Times reports that some experts need additional information, including confirmation that the baby had actually been infected, to determine if the case involved a cure or prevention of infection — prevention that can already be done for babies with infected mothers. The Times notes that unlike the expensive and dangerous treatment given to Timothy Brown, the aggressive pediatric treatment announced today could become "a new standard of care."

"Despite the fact that research has given us the tools to prevent mother-to-child transmission of HIV, many infants are unfortunately still born infected," said National Institute of Allergy and Infectious Diseases Director Anthony S. Fauci, MD. "With this case, it appears we may have not only a positive outcome for the particular child, but also a promising lead for additional research toward curing other children."

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Re: Scientists say child has been 'functionally cured' of HIV infection with early treatment

Post by ES on Tue Mar 05, 2013 1:29 pm

Great part on the people who made this possible, hope this will open new doors for the cure of cancer

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Re: Scientists say child has been 'functionally cured' of HIV infection with early treatment

Post by Targus on Tue Mar 05, 2013 5:56 pm

El Shaarawy wrote:Great part on the people who made this possible, hope this will open new doors for the cure of cancer

yeah great news,
but there are lots of people who found cure for cancer.

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Re: Scientists say child has been 'functionally cured' of HIV infection with early treatment

Post by RealGunner on Tue Mar 05, 2013 6:56 pm

Fantastic. Absolutely fantastic

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Re: Scientists say child has been 'functionally cured' of HIV infection with early treatment

Post by Forza on Tue Mar 05, 2013 11:42 pm

Great news. One issue is that this was a one-off occurrence. You don't know if they misdiagnosed the AIDS in the first place or something like that.

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Re: Scientists say child has been 'functionally cured' of HIV infection with early treatment

Post by McLewis on Wed Mar 06, 2013 3:46 pm

Another thing that I read about this is that this kid was cured primarily because they began treatment practically immediately after it was born. The virus didn't have time to assimilate itself into the baby's DNA so the treatment was able to do its job on it.

This presents a problem for older people, who's DNA is already infected with the virus because at that point, it's ridiculously difficult to separate the infected DNA strands from those that are not affected. So it appears this cure may be used primarily for newborns, but not too many other people unfortunately.

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Re: Scientists say child has been 'functionally cured' of HIV infection with early treatment

Post by Forza on Thu Mar 07, 2013 6:40 am

I won't get technical... here's a really, really, simple explanation of the way HIV works.

It infects a type of immune cell in your body. It replicates itself using the machinery of the cell and kills the immune cell. Once the numbers of these immune cells are really low, the body's immunity is reduced dramatically. What kills people is some other disease that comes along and takes advantage of this immune deficiency. So basically, you have to stop HIV before it takes out too many of these immune cells.

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Re: Scientists say child has been 'functionally cured' of HIV infection with early treatment

Post by vivabarca38 on Fri Mar 08, 2013 3:33 pm

@Targus wrote:
El Shaarawy wrote:Great part on the people who made this possible, hope this will open new doors for the cure of cancer

yeah great news,
but there are lots of people who found cure for cancer.

No,Just No.

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Re: Scientists say child has been 'functionally cured' of HIV infection with early treatment

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